Either increases toxicity of the other by QTc interval. quetiapine increases toxicity of benazepril by pharmacodynamic synergism. fluphenazine and quetiapine both increase sedation. Postmarketing cases show QT prolongation with overdose in patients with concomitant illness or with drugs known to cause electrolyte imbalance or prolong QT. erythromycin lactobionate will increase the level or effect of quetiapine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor. Use Caution/Monitor. Use Caution/Monitor. quetiapine, glimepiride. Use Caution/Monitor.quetiapine, desipramine. Monitor Closely (1)nelfinavir will increase the level or effect of quetiapine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. quetiapine and trifluoperazine both increase sedation. Monitor Closely (1)propofol and quetiapine both increase sedation. Avoid use with drugs that prolong QT and in patients with risk factors for prolonged QT interval. At the maximum recommended dose, deutetrabenazine does not prolong QT interval to a clinically relevant extent. oxybutynin topical decreases levels of quetiapine by pharmacodynamic antagonism. In patients of all ages who are started on antidepressant therapy, monitor closely for worsening, and for emergence of suicidal thoughts and behaviors. quetiapine, exenatide injectable solution. Objective The purpose of this study was to systematically review the efficacy, acceptability, and tolerability of quetiapine in adult patients with GAD. Postmarketing cases show QT prolongation with overdose in patients with concomitant illness or with drugs known to cause electrolyte imbalance or prolong QT. Advise patients to speak to physician or health care professional if pregnant, intend to become pregnant, or are breastfeeding. Use Caution/Monitor. lurasidone, quetiapine. Avoid use with drugs that prolong QT and in patients with risk factors for prolonged QT interval. Avoid use with drugs that prolong QT and in patients with risk factors for prolonged QT interval. This drug is available at a higher level co-pay. Avoid use with drugs that prolong QT and in patients with risk factors for prolonged QT interval. Monitor Closely (1)alprazolam and quetiapine both increase sedation. affecting hepatic/intestinal enzyme CYP3A4 metabolism. aripiprazole and quetiapine both increase QTc interval. Use Caution/Monitor. Avoid use with drugs that prolong QT and in patients with risk factors for prolonged QT interval. Use Caution/Monitor.butalbital and quetiapine both increase sedation. Dose reduction may be needed for coadministered drugs that are predominantly metabolized by CYP3A. Use Caution/Monitor. nafcillin will decrease the level or effect of quetiapine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Avoid or Use Alternate Drug. Closely monitor for signs of altered clinical response to either methylphenidate or an antipsychotic when using these drugs in combination. Serious - Use Alternative (1)quetiapine increases toxicity of vilanterol/fluticasone furoate inhaled by QTc interval. Use Caution/Monitor. Other (see comment). Either increases toxicity of the other by QTc interval. Monitor Closely (1)rufinamide will decrease the level or effect of quetiapine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Additive anticholinergic effects, possible hypoglycemia. quetiapine increases and phendimetrazine decreases sedation. Use Caution/Monitor.quetiapine, thioridazine. CYP3A4 substrates may require dosage adjustment. The forest plot of comparison of the mean changes from the baseline of the HAM-A scores (95% confidence interval) of quetiapine vs SSRIs in GAD. quetiapine increases effects of cyclizine by pharmacodynamic synergism. Monitor Closely (1)eletriptan, quetiapine. Monitor Closely (1)metaxalone and quetiapine both increase sedation. unspecified interaction mechanism. Monitor Closely (1)remimazolam, quetiapine. Serious - Use Alternative (1)hydroxychloroquine sulfate and quetiapine both increase QTc interval. Monitor Closely (1)verapamil will increase the level or effect of quetiapine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Monitor CYP3A4 substrates coadministered with stiripentol for increased or decreased effects. crizotinib and quetiapine both increase QTc interval. Effect of interaction is not clear, use caution. Postmarketing cases show QT prolongation with overdose in patients with concomitant illness or with drugs known to cause electrolyte imbalance or prolong QT. Additive anticholinergic effects, possible hypoglycemia.quetiapine, cyclobenzaprine. abobotulinumtoxinA increases effects of quetiapine by pharmacodynamic synergism. Serotonin modulators may enhance dopamine blockade, possibly increasing the risk for neuroleptic malignant syndrome. Either increases toxicity of the other by QTc interval. This site needs JavaScript to work properly. quetiapine and fostemsavir both increase QTc interval. Serious - Use Alternative (1)cimetidine will increase the level or effect of quetiapine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. ceritinib and quetiapine both increase QTc interval. Use Caution/Monitor. quetiapine increases effects of methscopolamine by pharmacodynamic synergism. Use Caution/Monitor. quetiapine, apomorphine. Antipsychotics may enhance serotonergic effect of serotonin modulators, which may result in serotonin syndrome. darifenacin decreases levels of quetiapine by inhibition of GI absorption. quetiapine and lofexidine both increase sedation. Comment: Atypical antipsychotics have been associated with hyperglycemia that may alter blood glucose control; monitor glucose levels closely. Use Caution/Monitor. Use Caution/Monitor.glycopyrrolate inhaled decreases levels of quetiapine by pharmacodynamic antagonism. rifapentine will decrease the level or effect of quetiapine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor. Use Caution/Monitor. Consider alternative anti-HCV therapy to avoid increases in quetiapine exposures; if coadministration is necessary, reduce quetiapine dose to 1/6th of current dose and monitor for quetiapine associated adverse reactions; refer to quetiapine prescribing information for recommendations on adverse reaction monitoring. Use Caution/Monitor. Avoid use with drugs that prolong QT and in patients with risk factors for prolonged QT interval. Monitor Closely (1)orphenadrine and quetiapine both increase sedation. Monitor Closely (1)butorphanol and quetiapine both increase sedation. Use Caution/Monitor. Talk to your doctor if you are using marijuana (cannabis).Quetiapine may cause a condition that affects the heart rhythm (QT prolongation). Use Caution/Monitor. Use Caution/Monitor. DHEA, herbal will increase the level or effect of quetiapine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Concomitant use of vemurafenib with drugs that prolong QT interval is not recommended. Either increases toxicity of the other by QTc interval. dabrafenib will decrease the level or effect of quetiapine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor. Monitor Closely (1)oxycodone and quetiapine both increase sedation. Use Caution/Monitor. inotuzumab and quetiapine both increase QTc interval. Additive anticholinergic effects, possible hypoglycemia. desflurane and quetiapine both increase sedation. Comment: Atypical antipsychotics have been associated with hyperglycemia that may alter blood glucose control; monitor glucose levels closely. Patients treated with selinexor may experience neurological toxicities. Monitor Closely (1)quetiapine, nateglinide. Use Caution/Monitor. Use Caution/Monitor. quetiapine increases effects of belladonna and opium by pharmacodynamic synergism. diphenhydramine decreases levels of quetiapine by pharmacodynamic antagonism. Effect of interaction is not clear, use caution. butorphanol and quetiapine both increase sedation. Either increases effects of the other by QTc interval. Comment: Atypical antipsychotics have been associated with hyperglycemia that may alter blood glucose control; monitor glucose levels closely. Use Caution/Monitor. Postmarketing cases show QT prolongation with overdose in patients with concomitant illness or with drugs known to cause electrolyte imbalance or prolong QT. quetiapine increases effects of atropine IV/IM by pharmacodynamic synergism. Avoid or Use Alternate Drug. Either increases toxicity of the other by QTc interval. Monitor Closely (1)quetiapine, disopyramide. Avoid or Use Alternate Drug. quetiapine, toremifene. Antipsychotics may enhance serotonergic effect of serotonin modulators, which may result in serotonin syndrome. Use Caution/Monitor. Use Caution/Monitor. Applies only to oral form of both agents. Encorafenib both inhibits and induces CYP3A4 at clinically relevant plasma concentrations. 2013 Nov;25(4):E7-22. Additive anticholinergic effects, possible hypoglycemia. Monitor Closely (1)opium tincture and quetiapine both increase sedation. Use Caution/Monitor. Serious - Use Alternative (1)macimorelin and quetiapine both increase QTc interval. Serious - Use Alternative (1)quetiapine decreases effects of levodopa inhaled by pharmacodynamic antagonism. Reserve concomitant prescribing of these drugs in patients for whom other treatment options are inadequate. Istradefylline 40 mg/day increased peak levels and AUC of CYP3A4 substrates in clinical trials. October 22, 2012 Seroquel (quetiapine) "This medicine is great for daytime anxiety or anxiety with insomnia. Other (see comment). Otherwise, call a poison control center right away. Other (see comment). dexamethasone will decrease the level or effect of quetiapine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Properly discard this product when it is expired or no longer needed. Use Caution/Monitor. Use Caution/Monitor. Antipsychotics may enhance serotonergic effect of serotonin modulators, which may result in serotonin syndrome. Either increases toxicity of the other by sedation. Avoid use with drugs that prolong QT and in patients with risk factors for prolonged QT interval. Discuss the risks and benefits of treatment with your doctor. Postmarketing cases show QT prolongation with overdose in patients with concomitant illness or with drugs known to cause electrolyte imbalance or prolong QT. Dosage adjustment may be necessary if lemborexant is coadministered with other CNS depressants because of potentially additive effects. Postmarketing cases show QT prolongation with overdose in patients with concomitant illness or with drugs known to cause electrolyte imbalance or prolong QT. Quetiapine Dosage Medically reviewed by Drugs.com. atracurium decreases levels of quetiapine by inhibition of GI absorption. Avoid or Use Alternate Drug. quetiapine increases effects of scopolamine by pharmacodynamic synergism. Use Caution/Monitor. Either increases toxicity of the other by QTc interval. primaquine and quetiapine both increase QTc interval. Avoid or Use Alternate Drug. Use Caution/Monitor. Postmarketing cases show QT prolongation with overdose in patients with concomitant illness or with drugs known to cause electrolyte imbalance or prolong QT. Additive anticholinergic effects, possible hypoglycemia. Slight and transient QT-prolongation observed with ezogabine, particularly when dose titrated to 1200 mg/day. Avoid use with drugs that prolong QT and in patients with risk factors for prolonged QT interval. Use Caution/Monitor. Use Caution/Monitor. Avoid or Use Alternate Drug. Avoid use with drugs that prolong QT and in patients with risk factors for prolonged QT interval. Monitor Closely (1)quetiapine, erythromycin ethylsuccinate. Either increases toxicity of the other by pharmacodynamic synergism. Modify Therapy/Monitor Closely. diphenhydramine and quetiapine both increase sedation. Monitor Closely (2)prochlorperazine and quetiapine both increase antidopaminergic effects, including extrapyramidal symptoms and neuroleptic malignant syndrome. quetiapine, iloperidone. Avoid or Use Alternate Drug. Postmarketing cases show QT prolongation with overdose in patients with concomitant illness or with drugs known to cause electrolyte imbalance or prolong QT. quetiapine and mirtazapine both increase sedation. Monitor Closely (2)quetiapine and maprotiline both increase sedation. Postmarketing cases show QT prolongation with overdose in patients with concomitant illness or with drugs known to cause electrolyte imbalance or prolong QT. Use Caution/Monitor. Monitor Closely (1)zolmitriptan, quetiapine. Use Caution/Monitor. Use Caution/Monitor. Antipsychotics may enhance serotonergic effect of serotonin modulators, which may result in serotonin syndrome. Use Caution/Monitor.pimozide and quetiapine both increase sedation. buprenorphine subdermal implant and quetiapine both increase QTc interval. Use Caution/Monitor. Monitor Closely (1)quetiapine, glyburide. Use Caution/Monitor. Quetiapine is a short-acting antipsychotic that is available in immediate and extended-release formulations. quetiapine increases effects of tolterodine by pharmacodynamic synergism. Use Caution/Monitor. Some conditions may become worse when this drug is suddenly stopped. Use Caution/Monitor. Avoid or Use Alternate Drug. Either increases toxicity of the other by QTc interval. Use Caution/Monitor. Monitor for evidence of serotonin toxicity (eg, mental status changes, autonomic instability, and neuromuscular hyperactivity) or neuroleptic malignant syndrome (eg, hyperthermia, muscle rigidity, autonomic dysfunction). Antipsychotics may enhance serotonergic effect of serotonin modulators, which may result in serotonin syndrome. Postmarketing cases show QT prolongation with overdose in patients with concomitant illness or with drugs known to cause electrolyte imbalance or prolong QT. Behav Ther. Use Caution/Monitor. Serious - Use Alternative (1)elvitegravir/cobicistat/emtricitabine/tenofovir DF increases levels of quetiapine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor. Use Caution/Monitor. Applies only to oral form of both agents. Postmarketing cases show QT prolongation with overdose in patients with concomitant illness or with drugs known to cause electrolyte imbalance or prolong QT. Quetiapine extended-release tablet is also used together with other antidepressants to treat major depressive disorder. doi:10.1097/JCP.0000000000001420, Crapanzano C, Damiani S, Guiot C. Quetiapine in the anxiety dimension of mood disorders: A systematic review of the literature to support clinical practice. Use Caution/Monitor. You may report side effects to FDA at 1-800-FDA-1088 or at www.fda.gov/medwatch.In Canada - Call your doctor for medical advice about side effects. Use Caution/Monitor. Postmarketing cases show QT prolongation with overdose in patients with concomitant illness or with drugs known to cause electrolyte imbalance or prolong QT. Use Caution/Monitor. Effect of interaction is not clear, use caution. Garakani A, Freire RC, Buono FD, Thom RP, Larkin K, Funaro MC, Salehi M, Perez-Rodriguez MM. Monitor Closely (1)mifepristone, quetiapine. St John's Wort will decrease the level or effect of quetiapine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Avoid use with drugs that prolong QT and in patients with risk factors for prolonged QT interval. Comment: Atypical antipsychotics have been associated with hyperglycemia that may alter blood glucose control; monitor glucose levels closely. Concomitant use stiripentol with other CNS depressants, including alcohol, may increase the risk of sedation and somnolence. Dose titration: Dose adjustments should be in increments no greater than 25 to 50 mg/day. unspecified interaction mechanism. Avoid use with drugs that prolong QT and in patients with risk factors for prolonged QT interval. Use of anticholinergic drugs after administration of botulinum toxin-containing products may potentiate systemic anticholinergic effects. unspecified interaction mechanism. amobarbital and quetiapine both increase sedation. Either increases toxicity of the other by Other (see comment). Additive anticholinergic effects, possible hypoglycemia. Crofelemer has the potential to inhibit CYP3A4 at concentrations expected in the gut; unlikely to inhibit systemically because minimally absorbed. Uses Warnings Before taking Dosage Side effects Interactions FAQ What is quetiapine? Applies only to oral form of both agents. Either increases toxicity of the other by QTc interval. Limit dosages and durations to the minimum required. Additive anticholinergic effects, possible hypoglycemia. Monitor Closely (1)quetiapine, vandetanib. quetiapine, artemether/lumefantrine. Increased risk of orthostatic hypotension. Postmarketing cases show QT prolongation with overdose in patients with concomitant illness or with drugs known to cause electrolyte imbalance or prolong QT. Serotonin modulators may enhance dopamine blockade, possibly increasing the risk for neuroleptic malignant syndrome.
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